SQUAMOUS CELL CARCINOMA (Definition - Pathology - Clinical Picture

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SQUAMOUS CELL CARCINOMA (Definition - Pathology - Clinical Picture - Treatment )

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Thursday, 10 December 2009 20:48

SQUAMOUS CELL CARCINOMA
"EPITHELIOMA"
Definition: Malignant tumour arising from the prickle cell layer of the epidermis. "epidermoid carcinoma".
Incidence: middle aged & elderly men.
Common Sites: any skin or mucous membrane lined by stratified squamous epithelium. Commonest in the face especially the lower lip.
Precancerous lesions:
1- Solar dermatitis. 2- Old scar or ulcer  Marjolin 's ulcer.
3- Post irradiation dermatitis. 4- Papillomas.
5- Xeroderma pigmentosa. 6- Rodent ulcer.

7- Lupus vulgaris (T.B. skin nodules).
Pathology & Cl. picture:
Mic: Cell nests = keratin in the center of mass of prickle cells showing malignant criteria.
Mac: The ulcer commonly in the lower lip with rapid growth showing raised everted edge, fixed indurated base and necrotic floor.
Spread: mainly direct & lymphatic spread rarely blood spread.
ؤ Sq. Cell carcinoma in the skin is well differentiated. than that of int. organs e.g. esophagus, with better prognosis in skin than esophagus.
Treatment:
1- Excision with safety margin then plastic reconstruction. Lymph nodes block dissection is not done except if it is involved.
2- Irradiation gives satisfactory results in some cases. It has the same indications and the contraindictions of rodent ulcer.
3- Electrodesiccation may be used in lesion less than 1cm and in elderly patients.
4- Mohs' surgery can be applied and is successful in treatment.
SOURCE: Prof. AYMAN SALEM'S BOOK
Copyright: (Vascular Society of Egypt ) & (Medical Educational web)
Not to be reproduced without permission of Vascular Society of Egypt

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