LYMPHOSARCOMA (Cause - Pathology - Clinical Picture

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LYMPHOSARCOMA (Cause - Pathology - Clinical Picture - Investigation- Treatment )

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Thursday, 10 December 2009 20:22

Incidence: The same incidence in children as Hodgkin but,. Adults are more affected than Hodgkin.
Pathology:
May involve any lymphatic tissue in the body, the commonest at
The neck (usually upper deep cervical L.N.)
Mediastinal.
Retroperitoneum. (the commonest retroperitoneal Tumor).
Small intestine. (The commonest malignant sarcoma of S.I).
Mac:
The affected group of nodes are amalgamated due to early infiltration of the cortex & capsule.
Cut section ® pale colour with areas of hge & necrosis.
Mic: Monomorphic; the lymphocytes are replaced by hyperchromatic malig. cells.
Clinical Features: 2 Forms may be met with:
(1) Localized form: the commonest.
One group affected gradually extend then disseminate.
The affected L.Ns are usually upper deep cervical L.N. which well be amalgamated and of variable consistency.
The skin over is stretched with dilated veins, which may ulcerate.
(2) Generalized Form:
All groups are enlarged from the start with rapid course.
Only blood picture can diff. it from lymphatic leukaemia.
It may terminate as lymphatic leukaemia.
Investigations: As any lymphadenopathy.
1- Complete blood picture.
2- X-ray © Plain chest x-ray © Lymphography.
3- Ultasonography & C.T. scan.
Treatment:
As Hodgkin but more radiosensitive but recurrence is more after radio therapy.
Surgery is only indicated for ® Biopsy
® Excision in early localized form.
SOURCE: Prof. AYMAN SALEM'S BOOK
Copyright: (Vascular Society of Egypt ) & (Medical Educational web)
Not to be reproduced without permission of Vascular Society of Egypt

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